Although Alzheimer’s disease (AD) is a neurodegenerative pathology characterized by accumulation of beta-amyloid plaques and neurofibrillary tangles at cerebral level, recent studies highlighted that AD might be the result of many altered physiological processes occurring at whole-organism level. The ability to adapt to stressors by “bending” but not “breaking” can be considered as “resilience”. This review explores what resilience means in the AD milieu and the physiological mechanisms by which physical activity may mediate positive adaptative processes that enhance resilience.
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